Established around 1796
First church: 1810
First parish priest: 1840

Around 1796, the first Acadian settlers arrived in this region. In 1798, the settlers received a visit from the first missionary to this part of the country. A first chapel was built in 1810. Having become too small, the construction of another began in 1828. Missionary priests residing in Richibouctou-Village served this region until the arrival of the first resident parish priest in 1840.
Saint-Louis was the birthplace of the great Acadian patriot, Bishop Marcel-François Richard. He was the one who had a third church built in 1876. It burned down in 1974, and the current church was built in 1975.
The nuns of the Congregation of Notre-Dame arrived in Saint-Louis in 1874. Their convent had a remarkable influence on the education of Acadian women. On August 23, 2009, a monument was unveiled to honour the nuns on the 135th anniversary of their arrival in Saint-Louis.
In 1878, Bishop Richard had a replica of the Lourdes Grotto erected in Saint-Louis, a monument still visited today.